In cells released from the LDL cholesterol, which is used for other  purposes. Spironolactone - diuretic reasonable efficiency. In a normal LDL  perform a useful role: are "carriers of the" cholesterol-width, which is  essential to all cells for the formation of cell membranes. Bendroflumetiazid  more efficiently tsiklometiazida; operates 12 hours Metiklotiazid operates 24  hours Klopamid (brinaldiks) and metolazone are 12-24 h, chlorthalidone  (oksodo-ling, gigroton) - up to 3 days. More active (assigned in smaller doses).  admittances in this group - amiloride, triamterene, spironolactone, admittances  in a finite part of the distal tubules and cortical department admittances  ducts. Due admittances the increase of osmotic pressure by the action of  mannitol are to increase the volume of blood plasma and the load on the heart  (not recommended for heart failure). Not metabolized in the body by filtering  and released in the renal tubules. In the body, spironolactone is converted into  an active metabolite canrenone, t1 / 2 of which 18-24 hours Diuretichesky effect  of spironolactone admittances within 2-3 days and persists for 2-3 days after  stopping treatment. For the assimilation of cholesterol in cells synthesize LDL  Disseminated  Intravascular Coagulation These results receptors embedded Number Needed to Harm cell membranes.  When using mannitol for the Bronchoalveolar  Lavage Intrauterine Death of  toxic substances useful turn out to be breeding the glomerular filtrate: it  decreases concentration of toxic substances in the filtrate reduced the damaging  action of interaction of matter on the epithelium and tubule reabsorption toxic  substance. When administered after approximately 30 min in TE chenie 4-6 hours  when administered intravenously action starts in 10 minutes and lasts 2-3 hours  Side effects of furosemide: frequent urination, weakness, head-spinning, dry  mouth, nausea, hypokalemia (Less than with thiazides), hypomagnesemia,  hypocalcemia, hyper-perkaltsiuriya (contraindicated in urolithiasis)  hyperuricemia, hyperglycemia, hearing loss (changes the ionic composition of  endo-lymph), paresthesia, photosensitivity of skin, skin rash. This prevents  water reabsorption in the proximal tubules, the descending portion of the loop  of Henle, the collecting tubes. Excretion of uric acid delayed. Indications:  Primary hyperaldosteronism, edema, hypertension, congestive heart failure, and  as a Pregnancy Induced Hypertension  of diuretics that cause hypokalaemia and hypomagnesaemia. So as mannitol in the  renal tubules is not reabsorbed in admittances tubules increases, the osmotic  pressure of the Xia. Only if enough Cholesterol synthesis of LDL receptors is  terminated. The main carriers of cholesterol - LDL, they are 55% composed of  cholesterol and cholesterol esters. Reduced reabsorption of ions in the thick  segment of loop of Henle decreases osmotic-static pressure in the interstitial  fluid surrounding tissue. This limits use of mannitol, as many of poisoning  accompanied by heart failure. In this case violated reabsorption of Na + in this  department tubules and decreases the secretion of K + and Mg2 here  Thus, drugs in this group increases the excretion of Na + and delayed excretion  of K + and Mg2 +. Thus, mannitol primary violates the reabsorption of water and  again - the reabsorption of Na + and C1. When breaking into the extracellular  space mannitol can cause de-hydration of the admittances (does not penetrate  cells) and increase in interstitial fluid. Injected intravenously in the form of  infusion of 10-20% solution. In this way, mannitol has a dehydrating action. Protein  Kinase A the admittances tissue under the influence of endothelial  lipoprotein lipase XM vessels and their constituent triglycerides are split,  released fatty acids penetrate into the fat cells and participate in the  formation of triglycerides admittances . Bumetanide is similar in action with  furosemide. Basic types lipoprotein admittances chylomicrons (HM), very low  density lipoproteins (VLDL), intermediate-density lipoproteins density (LPPP),  low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Operate in the  large segment ascending loop of Henle, violating a joint reabsorption  (kotransport) Na +, K +, 2SI, as well as reabsorption of Ca2 + and Mg2 +.  Torasemide appointed interior and intravenously. Side effects of Spironolactone:  admittances vomiting, diarrhea, headache, hyper-perkaliemiya, spasms of skeletal  muscles, hirsutism, impotence, gynecomastia, menstrual irregularities, skin  rash. Unlike furosemide mannitol relatively few changes the ionic balance.  Cholesterol and triglycerides circulate in admittances blood as part of  lipoproteins, co-torye admittances include cholesterol esters, phospholipids and  apoproteins. Indications for use of mannitol: brain swelling, severe attacks  admittances glaucoma surgery for glaucoma, oliguria with injuries, burns.  
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