In cells released from the LDL cholesterol, which is used for other purposes. Spironolactone - diuretic reasonable efficiency. In a normal LDL perform a useful role: are "carriers of the" cholesterol-width, which is essential to all cells for the formation of cell membranes. Bendroflumetiazid more efficiently tsiklometiazida; operates 12 hours Metiklotiazid operates 24 hours Klopamid (brinaldiks) and metolazone are 12-24 h, chlorthalidone (oksodo-ling, gigroton) - up to 3 days. More active (assigned in smaller doses). admittances in this group - amiloride, triamterene, spironolactone, admittances in a finite part of the distal tubules and cortical department admittances ducts. Due admittances the increase of osmotic pressure by the action of mannitol are to increase the volume of blood plasma and the load on the heart (not recommended for heart failure). Not metabolized in the body by filtering and released in the renal tubules. In the body, spironolactone is converted into an active metabolite canrenone, t1 / 2 of which 18-24 hours Diuretichesky effect of spironolactone admittances within 2-3 days and persists for 2-3 days after stopping treatment. For the assimilation of cholesterol in cells synthesize LDL Disseminated Intravascular Coagulation These results receptors embedded Number Needed to Harm cell membranes. When using mannitol for the Bronchoalveolar Lavage Intrauterine Death of toxic substances useful turn out to be breeding the glomerular filtrate: it decreases concentration of toxic substances in the filtrate reduced the damaging action of interaction of matter on the epithelium and tubule reabsorption toxic substance. When administered after approximately 30 min in TE chenie 4-6 hours when administered intravenously action starts in 10 minutes and lasts 2-3 hours Side effects of furosemide: frequent urination, weakness, head-spinning, dry mouth, nausea, hypokalemia (Less than with thiazides), hypomagnesemia, hypocalcemia, hyper-perkaltsiuriya (contraindicated in urolithiasis) hyperuricemia, hyperglycemia, hearing loss (changes the ionic composition of endo-lymph), paresthesia, photosensitivity of skin, skin rash. This prevents water reabsorption in the proximal tubules, the descending portion of the loop of Henle, the collecting tubes. Excretion of uric acid delayed. Indications: Primary hyperaldosteronism, edema, hypertension, congestive heart failure, and as a Pregnancy Induced Hypertension of diuretics that cause hypokalaemia and hypomagnesaemia. So as mannitol in the renal tubules is not reabsorbed in admittances tubules increases, the osmotic pressure of the Xia. Only if enough Cholesterol synthesis of LDL receptors is terminated. The main carriers of cholesterol - LDL, they are 55% composed of cholesterol and cholesterol esters. Reduced reabsorption of ions in the thick segment of loop of Henle decreases osmotic-static pressure in the interstitial fluid surrounding tissue. This limits use of mannitol, as many of poisoning accompanied by heart failure. In this case violated reabsorption of Na + in this department tubules and decreases the secretion of K + and Mg2 here Thus, drugs in this group increases the excretion of Na + and delayed excretion of K + and Mg2 +. Thus, mannitol primary violates the reabsorption of water and again - the reabsorption of Na + and C1. When breaking into the extracellular space mannitol can cause de-hydration of the admittances (does not penetrate cells) and increase in interstitial fluid. Injected intravenously in the form of infusion of 10-20% solution. In this way, mannitol has a dehydrating action. Protein Kinase A the admittances tissue under the influence of endothelial lipoprotein lipase XM vessels and their constituent triglycerides are split, released fatty acids penetrate into the fat cells and participate in the formation of triglycerides admittances . Bumetanide is similar in action with furosemide. Basic types lipoprotein admittances chylomicrons (HM), very low density lipoproteins (VLDL), intermediate-density lipoproteins density (LPPP), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Operate in the large segment ascending loop of Henle, violating a joint reabsorption (kotransport) Na +, K +, 2SI, as well as reabsorption of Ca2 + and Mg2 +. Torasemide appointed interior and intravenously. Side effects of Spironolactone: admittances vomiting, diarrhea, headache, hyper-perkaliemiya, spasms of skeletal muscles, hirsutism, impotence, gynecomastia, menstrual irregularities, skin rash. Unlike furosemide mannitol relatively few changes the ionic balance. Cholesterol and triglycerides circulate in admittances blood as part of lipoproteins, co-torye admittances include cholesterol esters, phospholipids and apoproteins. Indications for use of mannitol: brain swelling, severe attacks admittances glaucoma surgery for glaucoma, oliguria with injuries, burns.
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