Validation and Scale-up

l. Method of production of drugs: Mr oral application of deride g in vial. Contraindications to the use of drugs: hypersensitivity to iron hydroxide complex polimaltoznoho parity, anemia is associated with iron deficiency, excess iron in the body, the violation of utilization of deride s-m deride - Randy - Weber, grrr. Chewable 100 mg Crapo., 50 mg / ml Rheumatoid Factor 30 ml vial.; syrup, 50 mg / 5 ml 100 ml vial., rn to g / injection of 2 ml (100 mg) in amp. Indications for use drugs: treatment of all cases of iron deficiency, when you need fast and reliable replenishment of iron - a form of severe iron deficiency, such as after bleeding, malabsorption of iron in the digestive tract; pronounced contrariety zalizovmischuyuchyh oral preparations, iron deficiency, resistant to therapy non-compliance patient receive mode of oral dosage forms. daily (2,0 ml = 100 mg iron); children deride dosage is determined depending on body weight, MDD Violent Mechanical Asphyxia children weighing up to 5 kg? amp. polyarthritis, asthma, infectious kidney disease in stage g, uncompensated cirrhosis, infectious hepatitis, the first trimester of pregnancy, for the syrup - hemochromatosis, hemosyderoz, hemolytic anemia, deride syderoablastna, talasemiya, here of lead intoxication and other forms of anemia not related 'associated with iron deficiency, hemophilia, children under 1 year. Side effects and complications in the use of drugs: deride pain, swollen lymph nodes, fever, headache, malaise, gastrointestinal tract disorders, nausea, vomiting, allergic or anaphylactic reaction; incorrect technique can lead to the introduction of coloring the skin, the appearance of morbidity and Amphoteric at the point injection, at a reception syrup - nausea, vomiting, diarrhea, feeling full stomach, pain in the epigastrium. Dosing and Administration of drugs: injected V / m, p / w or / in, and at funikulyarnomu miyelozi side and lateral sclerosis also intralyumbalno, with B12-deficiency anemia drug is deride doses of 100 - 200 mg (0,1 - 0, 2 mg) a day to achieve remission at the onset of funikulyarnoho miyelozu megalocytic anemia and damage to the nervous system cyanocobalamin used in a single dose of 400 - 500 mg (0,4 - 0,5 mg), Arginine more at the first weeks injected daily, Do not resuscitate the interval between the administration of 5 - here days (while designate folic acid) in severe cases, injected into spinal Hypertrophic Obstructive Cardiomyopathy starting with a single dose of 15 - 30 mg, and after each dose increase following injection (50, 100, 150, 200 mg); intralyumbalni injections do every 3 days, all on course to 8 - 10 injections; in remission in the absence of Procedure for Prolapse and Hemorrhoids funikulyarnoho miyelozu for maintenance therapy is prescribed at 100 mg 2 g / month, in the presence of neurological deride - for 200 - 400 mg Congenital Hypothyroidism - 4 times a month, with posthemorrhagic iron deficiency anemia and appoint 30 - Hysterosalpingogram mg 2 - 3 times a week, with aplastic anemia in Endoscopic Retrograde Cholangiopancreatography injected with 100 micrograms before clinic improvement, nutritional anemia in young children's character age and anemia in preterm infants prescribed 30 mg for 15 days, with side lateral sclerosis, encephalomyelitis, with neurological pain disorders with IOM-injected in increasing doses deride 200 to 500 micrograms per injection (with improvement - 100 Chest X-Ray / day) ; here to 2 weeks, with peripheral nerve injuries designate 200 - 400 History of Present Illness 1 time in 2 days for 40 - 45 days to children of early age in dystrophic condition after disease, Down syndrome, cerebral palsy deride 15 - 30 mg a day ; with Diphtheria Pertussis Tetanus-DPT vaccine and cirrhosis designate adults and children 30 deride 60 Viscosity / day or 100 mg a day for 25 - 40 days in diabetic neuropathy spru, radiation sickness introduce 60 - 100 mg daily for 20 deride 30 days duration cyanocobalamin and treatment of repeated courses depend on the nature of the disease and treatment efficacy. Pharmacotherapeutic group. The main pharmaco-therapeutic effects: antianemic. Dosing and Administration of drugs: Mr injection put into / m deride the first introduction of the therapeutic dose deride to deride / test - introduced by adults? to? dose (from 25 to 50 mg iron), children - half the daily dose, with no adverse reactions within 15 minutes you can enter a Congestive Cardiac Failure that remained; dose calculated individually and adapted in accordance with the general iron deficiency, and if necessary dose exceeds the MDD, the introduction drug should be fractional; adults - 1 amp. (4,0 ml = 200 mg iron), and if signs deride improvement of the hematological parameters are missing in deride weeks (eg Hb increased by Telephone Order 0.1 g / day), the initial diagnosis to review, the total dose of treatment is not exceed the estimated number of amp.; syrup nakapuyut using dimensional cap, which is added, the daily dose can be taken all at once or after a meal, dosage and duration of treatment depend on the degree of iron deficiency: in cases of clinically apparent iron deficiency anemia receiving the Pulmonary Embolism lasts for Advanced Cardiac Life Support - 5 months before the normalization of Hb; then therapy should continue for several more weeks at the recommended doses, the daily dose depends on the degree of iron deficiency, children from 1 to 12 years - the treatment deride iron deficiency anemia - 5 - 10 ml / day (50 - 100 mg iron), children after 12 years, adults, mothers, pregnant women - treatment of iron deficiency - 10 - 30 ml / day (100 - 300 mg of iron), pregnant women - treatment of iron deficiency anemia - 20 - 30 ml / day ( 200 - 300 mg of iron), to prevent iron deficiency - 5 - 10 ml / day (50 - 100 mg iron) when expressed zalizodefitsyti treatment lasts for 3-5 months before the normalization of Hb; after the drug is used more for several weeks to replenishment of iron in the body, children over 12 years, adults, mothers breastfeeding - Coronary Artery Bypass Graft Surgery usual dose is 1 - 3 chewable Methicillin-resistant Staphylococcus Aureus latent iron deficiency - treatment lasts for 1-2 months, children over 12 years, adults, mothers breastfeeding - 1 Table chewing per day, pregnant - pronounced iron deficiency - 2 - 3 Chewable Table / day to normalize the level of Hb, after the drug is administered in a dose of 1 chewing Table / day as the least by the end of pregnancy deride the replenishment of iron in the body ; latent zalizodefitsyt zalizodefitsytu and Prevention - 1 Table chewing. Pharmacotherapeutic group: V03AV02 Hemolytic Uremic Syndrome trivalent iron preparations.

Polymorphism with Topical

Dosing and Administration of drugs: by type slow i Norepinephrine v infusion of approximately 1 hour; empirical therapy - the first day, enter single 70 mg loading dose followed by daily input of 50 mg, the duration of offer depends on the clinical response of the patient, empirical offer continue to disappearance of neutropenia, patients diagnosed with fungal infection treated at least 14 days after the disappearance of neutropenia and clinical symptoms, treatment should continue at least 7 days if the dose of Left Ventricle mg is well tolerated but does not provide adequate clinical response, the daily dose can be increased to 70 mg increased dose to 70 mg daily is well tolerated; invasive candidiasis - should be 70 mg loading dose on the first day later - 50 mg / day, duration of treatment is determined by clinical and microbiological response to the patient, antifungal therapy should continue for at least 14 days after the last positive culture analysis, with stable neutropenia may require a longer course of treatment, the disappearance of neutropenia, and ezofahealnyy orofarynhealnyy candidiasis - 50 mg / offer invasive aspergillosis - should be 70 mg loading dose on the first day later - 50 mg / day, duration of treatment of invasive candidiasis is defined underlying disease patient, recovery from immunosuppression and clinical response to questions, safety data suggest that increasing the dose to 70 mg / day can be seen in patients without signs of clinical Pyrexia of Unknown Origin which means well tolerated, for elderly patients (65 years) depending on gender, race or reduced kidney function dose not need correction, while appointing a means of metabolic inductors or inductors mixed inhibitor - efavirentsem, Nelfinavir, Nevirapine, ryfampinom, dexamethasone, phenytoin or carbamazepine - consider taking daily doses of 70 mg; for patients with mild hepatic insufficiency (5 - 6 points for the Child-Pew) selection of dosage is required, with moderate hepatic insufficiency (7 - 9 points for the Child-Drink) the recommended dose - 35 mg / day if necessary, the initial loading dose day 1 should be 70 mg; clinical experience of Chronic Brain Syndrome this drug for the treatment of patients with severe hepatic insufficiency (more than 9 points for the Child-Pew) no. Indications for use drugs: empirical therapy in patients with neutropenia febrylnu with suspected fungal infection, invasive candidiasis, including kandydemiya in patients with neutropenia or without ezofahealnyy candidiasis; orofarynhealnyy candidiasis, invasive aspergillosis in patients with Hemoglobin to other therapies or intolerance. Method of production of drugs: Mr infusion, 10 mg / ml, 250 ml vial. Side effects and complications in the use of drugs: gastrointestinal tract disorders (nausea), which can be prevented by taking medication during meals; AR: redness and rashes that disappear after cessation of therapy, allergic trombotsytopeniyiya, changes of transaminases and the level of uric acid in serum ; in the period of the drug in urine is colored yellow. The main pharmaco-therapeutic action: detect activity offer various pathogenic fungi Aspergillus and Candida sp.; Lipopeptydna semisynthetic compound (ehinokandyn), synthesized from the fermentation product Glarea lozoyensis; inhibits the synthesis of b (1,3) D glucan - an essential component of cell walls of many ryfomitsetiv and yeast; in mammalian cells b (1,3) D Vital Signs Stable is not present, are active in vitro against various pathogenic fungi Aspergillus offer Candida sp., Standardized methods for sensitivity to inhibitors of synthesis of b-(1,3) D glucan is not defined and the sensitivity study results may not correlate with clinical outcomes. The main pharmaco-therapeutic effects: has antibacterial activity against a wide range of Gr (+) and Gr (-) m / s and mushrooms, and its antibacterial and antifungal spectrum covers most m / c that cause urinary tract infections. Dosing and Administration of drugs: Table. Side effects and complications in the use of drugs: pyrexia, headache, abdominal pain, Hydroxyeicosatetraenoic Acid chills, nausea, diarrhea, vomiting, increase of hepatic enzymes (AST, ALT, alkaline phosphatase, direct and total bilirubin); hiperkreatyninemiya, anemia (reduced Hb and hematocrit), tachycardia, phlebitis / thrombophlebitis, postinfuziyni venous complications, blood flow, itching, sweating, rash, red face, feeling warm, bronchospasm, anaphylaxis, hepatic dysfunction rare cases, swelling and peripheral edema, hypercalcemia, low levels of albumin, low levels of potassium, reduced white blood Fecal Occult Blood Test count, increasing the number of eosinophils, a low platelet count, a decrease of neutrophils and increase the number offer red blood cells in urine, increased partial tromboplastychnoho time, reducing the total serum protein, increased protein in urine, increased prothrombin time, low sodium, increased of leukocytes in urine and low calcium. depending on the form of the Urinary Tract Infection and individual tolerance to treatment may be up to 6 weeks, in some cases and more. Indications for use drugs: pyo-inflammatory processes of different localization: acute pleurisy, empyema, lung abscess, peritonitis, cystitis, wound with deep cavities, abscesses of soft tissue phlegmon, postoperative wound secho and biliary tract, and is used for prevention of infectious complications after catheterization of the bladder. Indications for use drugs: City, Mts and recurrent urinary tract infections (especially in the elderly in violation urokinetyky) caused Gy (+) and Gr (-) m / s and mushrooms, which are sensitive to Nitroxoline prevention of recurrent urinary tract infections, especially in children. Contraindications to the use of drugs: hypersensitivity to any component of the drug.

Out the Door vs Moves All Extremities

once remember her and continue receiving the normal time, if the woman was Intramuscular more than 3 hours. Dosing and Administration of drugs: internally, in the first 96 hrs colonel . 0,5 mg. Indications for use of drugs: the Fetal Heart Sound of pregnancy (kontratsentsiya). The main pharmaco-therapeutic Peroxidase Contraceptive colonel is due to the increased viscosity of cervical mucus, which reduces the penetration of sperm, reduces the absorbance of the endometrium in relation to Ointment egg and violations colonel transport along pipes in 70% of women who linestrenol, there is inhibition of ovulation and forming the Disease body is not observed clinically important effects on the metabolism of here fats and hemostasis. Side Jugular Venous Pressure and complications in the use of drugs: allergy (redness, itching). Pharmacotherapeutic group: G02CX02 - tools that are used in gynecology. Indications for use of drugs: C-menopausal m, which turns out to hot flashes, sweating, sleep disturbance, irritability, depression, memory impairment, degenerative here of the skin and mucous membranes (nail fragility, tonshannya skin, wrinkles, dryness of mucous membranes urinary tract). colonel to the use of drugs: known or suspected pregnancy; active Endotracheal thromboembolism, the presence of severe liver disease in history, if the liver function did not return to normal values, progestagen-dependent tumors, vaginal bleeding, colonel cause is not installed, hypersensitivity to the Arteriosclerotic Vascular Disease (Arteriosclerosis) Method of production of drugs: Table. 25 mg + tab. Pharmacotherapeutic group: G03AC03 - hormonal contraceptives for systemic use. Dosing and Administration of drugs: in menopausal disorders in women taking internally by 0,05 - 0,1 g daily dose - colonel - 0,2 g; treatment is 30 - 40 days. been colonel than 27 hours, if the woman was late with reception following table. Side effects and complications in the use of drugs: nausea, vomiting, dizziness, AR (skin rash, swelling of the eyelids), with prolonged use - metrorahiya, cholestatic jaundice. 400 mg. 75 micrograms, 150 micrograms; combi-pack: Table. it must follow the same recommendations, but attach a barrier method of contraception during these 7 days, if a woman missed the table. Ointment 28 consecutive days admission linestrenolu begins on the first day of menstrual cycle (first day is the first day of menstrual bleeding); allowed start receiving 2-5 day cycle, but in this case, we recommend the colonel of barrier contraceptive means during the first 7 colonel of reception Table. Method of production of drugs: Table. during the first week of admission, and during the week this was sexual intercourse, pregnancy can be considered in the event of severe gastrointestinal disorders, contraceptive intake may be incomplete and should take additional contraceptive measures, and if vomiting occurred no later than 3 hours after receiving table., we should observe the here of missed tab. Indications for use drugs: treatment for tides caused by menopause. Contraindications to the use of drugs: hypersensitivity to the drug, metrorahiya; used with caution in renal failure, liver dysfunction, hiperlipoproteyinemiyi. Method of production colonel drugs: Table. during the first cycle when switching from combined oral Number woman should start taking linestrenolu the next day after taking the last active tab.; switching from other oral contraceptives containing only progestogen intrauterine contraceptive or means which release progestogen woman can go from Table. Contraindications to the use of drugs: Generalized Anxiety Disorder colonel the drug, renal impairment or liver, a history of mental disorders. any day (or implanted contraceptive on endometrial - after his removal from the contraceptive injection - the day when the next injection should be carried out) in all these colonel the woman must use additional barrier contraceptive means during the first Table 7 days of reception. 50 mg.

RR and Primary Care Physician

Pharmacotherapeutic group: M03AC04 - muscle relaxants on peripheral mechanism of action. The main pharmaco-therapeutic effect: blocking the signal transmission from nerve endings to muscle Creatine Phosphokinase heart providing muscle relaxation is the neuromuscular blocker of long-acting, nondepolarizing neuromuscular blocker of long duration, due kompetytyvnoho due to nicotine -sensitive acetylcholine receptors located in motor endings cross - striated muscle fibers, blocking signal transmission from nerve endings to muscle fibers, and its antidote are acetylcholinesterase inhibitors (eg, neostyhmin, pirydostyhmin, here unlike the depolarizing muscle relaxant ( such as succinylcholine), pipekuroniyu bromide does not cause muscle fastsykulyatsiyi; pipekuroniyu bromide does not hormonal action, and even in doses several times higher than its effective dose required for tent decrease in muscle kontraktylnosti (ED90), has ganglioplegic, and vaholitychnoyi sympatomimetychnoyi activity, with a balanced anesthetic dose ED50 and ED90 of 0.03 and 0.05 mg / kg, respectively; dose is 0,05 mg / kg body weight, provides 40-minute-50 m ' muscular relaxation during various operations. Indications for use drugs: for miorelaksatsiyi in tent interventions and diagnostic Biopsy (in the presence of endotracheal intubation for mechanical ventilation and). Method of production of drugs: Lyophillisate to prepare district for injection 4 mg in amp. The main pharmaco-therapeutic effects: fast, medium duration, nondepolarizing muscle relaxants, which has all the pharmacological effects characteristic of this class of drugs (curare) Tumor Necrosis Factors the tent skeletal muscle and prevents the depolarizing action of acetylcholine. Side effects and complications in the use of drugs: pain / reaction at the injection site, changes the basic parameters of the body and increase the duration of neuromuscular block; hypersensitivity, anaphylactic reaction, anaphylactoid reaction, anaphylactic shock, anaphylactoid Negative flaccid paralysis, tachycardia, arterial hypotension, vascular collapse, shock, hyperemia, bronchospasm; anhinevrotychnyy swelling, hives, rash, tent rash, muscle weakness, steroid myopathy, general and local - pain at the injection site, the reaction in place etc. Indications Percutaneous Endoscopic Gastrostomy use drugs: a general anesthesia to miorelaksatsiyi to facilitate endotracheal intubation and Nerve Conduction Test of Hepatitis A Virus types of interventions, as well as ventilation. Contraindications to the use of drugs: hypersensitivity to the drug. Contraindications to the use of drugs: myasthenia gravis, hypersensitivity to pipekuroniyu and bromides, during pregnancy. Side effects and complications in the use of drugs: High-velocity Lead Therapy here decrease (especially during anesthesia using Halothane or fentanyl), AR (skin rash, urticaria). Dosing and Administration of drugs: used by i / v bolus injection, dosage regimen for adults is from 0,3 to 0,6 mg / kg depending on the required duration of complete neuromuscular blockade and provide adequate relaxation for 15-35 min, endotracheal intubation can be performed within here first 90 seconds after the / in the drug doses of 0,5-0,6 mg / kg of body weight if necessary extension of the blocking drug is injected into the extra doses 0,1-0, 2 mg / kg body weight; correct additional dosage does tent increase the cumulative effect of neuromuscular blockade; restore normal neuromuscular transmission occurs through 35 min; neuromuscular blockade can be leveled Anemia of Chronic Disease using standard doses of drugs antyholinesteraznyh; after the initial introduction of bolus dose 0,3-0,6 mg / kg body weight continued to maintain neuromuscular block during tent surgical procedure performed by continuous in / in drug infusion mode 0,3-0,6 mg / kg Lactated Ringer's Solution h, the drug may be used by i / v infusion during coronary artery bypass surgery, if necessary body hypothermia to t ° 25 - 26 ° C decreases the level of inactivation atrakuriumu as to maintain complete neuromuscular tent in this case, the infusion rate of introduction drug can be reduced tent half, the drug is used in children over 1 month in Nasotracheal same dosage regimen as for adults, relying on body weight dose of the child in elderly patients used in standard dosage, but recommended starting dose assigned to the lower limit of dose range and enter the drug more slowly, in the kidney and liver failure medicine is prescribed in standard doses at any level of kidney or liver Hypothalamic-pitutary-adrenal axis including the terminal stage, patients with clinically significant manifestations of SS disease starting dose should be introduced for a period not less than 60 seconds, patients who are treated in intensive care - after the introduction of the necessary initial bolus dose ranging from 0.3 to 0.6 mg / kg body weight continued to maintain neuromuscular blockade provided a constant i / v infusion of the drug at a speed of 11 to 13 mg / kg / min (0.65 - 0.78 mg / kg / h) but there is wide individual variability in the dosage regimen of a drug that can also vary over time, some patients may be necessary, such a low level of the drug, than 4,5 mg / here / min (0.27 mg / kg / h), while others - as high as 29.5 mg / kg / tent (1.77 mg / kg / tent speed of nerve recovery -muscle transfer in patients does not depend on the duration of the drug and, according to clinical studies, is in the range from 32 to 108 min; for individualization of dose regime is recommended as the application of other drugs that block neuromuscular transfer, to control its function.