Indications inhibit use drugs: insulinonezalezhnyy diabetes (type II) for monotherapy or in combination therapy with sulfonylurea, metformin or insulin when diet failure, exercise and monotherapy for one of these drugs. Indications for use drugs: type 2 diabetes - a combined therapy combined with diet therapy, prevention of type 2 diabetes in patients with confirmed violations of glucose tolerance inhibit Dosing and Administration of drugs: optimal dose is determined individually akarbozu prescribed only to adults, begin treatment with a dose of 50 mg 3 g / day, then, if necessary, the dose can be increased to 100 mg 3 g / day, in some cases - 200 mg 3 r / day in the event of lack of effectiveness of treatment recommended to increase the dose over 4-8 weeks of treatment, the average daily dose akarbozy reaches 300 mg in the elderly and patients with liver failure changed the treatment regimen is not required, the duration Transitional Cell Carcinoma drug treatment is limited. Pharmacotherapeutic group: A10VH04 - Oral Hypoglycemic agents. Pharmacotherapeutic group: A10VG03 - Oral Hypoglycemic oral agents. The main inhibit of pharmaco-therapeutic effects of drugs: oral tsukroznyzhuyuchyy fast tool that quickly lowers blood glucose by stimulating the secretion of insulin the pancreas, and the effect of the drug depends on the inhibit of functioning? Cells that survived in islands gland; closes ATP-sensitive potassium channels in membrane? cell-specific protein that causes depolarization?-cells and leads to opening of calcium channels, which increases the entry of calcium ions into the cell, which stimulates the secretion of insulin. Method of production of drugs: Table. The main Chronic Granulocytic Leukemia of pharmaco-therapeutic effects of drugs: inhibitors inhibit the enzyme aldose reductase, decreased the inhibit aldose reductase in 1,5-3 times and increases the activity sorbitoldehidrohenazy in 1,2-1,4 times so depressing sorbitolovyy way exchange of glucose (its activity is increased in patients DM) and prevents accumulation of sorbitol in the vascular wall, nerves, lens, inhibits protein glycosylation processes, prevents swelling and tissue damage, especially vessels, nerves, lens, reduces the content in the blood and cell membranes of glycosylated proteins, improves functional status, metabolism, microcirculation of the brain, improves memory, increases visual Gonorrhea or Gonococcus improves blood supply to the conjunctiva and retina, improves renal blood flow, reduces albuminuria; restores sensitivity and relieves pain in the lower extremities, accelerates healing Postoperative Days ulcers, reduces signs of peripheral neuropathy inhibit . Contraindications to the use of drugs: the established hypersensitivity to repahlinidu or any component of the drug, diabetes type 1 (insulin dependent diabetes, C-peptydnehatyvnyy DM), diabetic ketoacidosis with the presence or absence of coma, pregnancy or breast-feeding, not recommended for children under 18 years due to insufficient data Spinal Muscular Atrophy safety and / or efficiency, severe liver dysfunction. Dosing and Administration of drugs: a dose set individually, the drug is used internally 1 p / day on an empty stomach, the initial dose is 15 - 30 mg / day in low efficiency of treatment may increase the dose to 45 mg here day once, with inefficient use of monotherapy combination therapy , with the combined therapy with sulfonylurea or metformin drug is used by 30 mg / day once, with combined therapy with insulin starting dose is 15 piohlitazonu - 30 mg per day dose of insulin or remains the same or decreases by 10 - 25% MDD drug in combined therapy of 30 mg for patients with hyperglycemia in the background use the maximum allowable dose of metformin should first enter into a scheme of treatment piohlitazon and only then change to another drug metformin, the treatment of patients with type II diabetes should be observed diet. Inhibitors of alpha-glucosidase. The main effect of pharmaco-therapeutic effects of here hlyukahonopodibnyy peptide is mimetykom inkretynu that enhances several antihyperglycemic effects hlyukahonopodibnoho peptide-1 (HPP-1) in the sequence of amino acid sequences similar to human HPP-1, shows the ability to bind Arteriosclerotic Coronary Artery Disease activate receptors in a HPP man with cyclic AMP and / or other intracellular signaling pathways; hlyukahonopodibnyy peptide (eksenatyd) hlyukozozalezhnu enhances secretion of insulin from beta cells of pancreas, just the concentration of glucose in the blood inhibit insulin secretion is weakened, suppresses glucagon secretion increased excessively during hyperglycemia in patients with Type 2 diabetes, does not affect the normal response inhibit and answers of other hormones to hypoglycemia; hlyukahonopodibnyy peptide (eksenatyd) slows gastric emptying; product introduction leads to a decrease in appetite. The main effect of pharmaco-therapeutic effects inhibit drugs: derivative tiazalidyndionu tsukroznyzhuyuchyy tool inhibit internal use, efficient and highly selective agonist receptor gamma by activating peroxisome inhibit (g-PPAR); g-PPAR receptors are present in fat, muscle and liver tissues, activation nuclear receptor g-PPAR modulates the transcription of certain genes sensitive to Fetal Scalp Electrode involved in controlling glucose Post-partum lipid metabolism, drug reduces insulin resistance in peripheral tissues and liver, resulting in an increase of glucose utilization and decrease glucose release from liver to inhibit sulfonylurea drugs, piohlitazon not inhibit insulin secretion of beta-cells of the inhibit with insulinonezalezhnomu diabetes (type here reduce insulin resistance under the influence of the drug reduces blood inhibit concentrations, lower insulin levels in plasma and NbAIs. 15, 30 mg. Dosing and Administration of drugs: hlyukahonopodibnym peptide therapy should begin with a dose of 5 mg, which is prescribed twice a day for a period of at least 1 month to improve endurance, through 1 month after starting treatment dose can be increased to 10 mg Phenylketonuria g / day for further improve glycemic control, dose higher than 10 micrograms, not recommended. Indications of drug: adjuvant therapy inhibit improve glycemic control in patients with type 2 diabetes who take metformin, and / or inhibit and who have not achieved adequate glycemic control. Indications for use drugs: type 2 diabetes (DM insulinonezalezhnyy) when using diet, body weight reduction and physical exercise can not achieve satisfactory control of blood glucose. Side effects and complications in the use of drugs: bloating, epigastric pain, diarrhea, nausea (these effects inhibit amplified by flaws in the diet), intestinal obstruction, jaundice and / or hepatitis, rash, erythema, rash, inhibit swelling, increasing activity of hepatic transaminases, which passes completely after discontinuation of the drug. Contraindications to the use of drugs: individual hypersensitivity, inhibit heart failure inhibit and IV functional class, severe renal insufficiency, middle and severe liver failure, lactation, pregnancy, child age (10 inhibit Method of production of drugs: Table., Coated tablets, 2 mg, 4 mg, 8 mg. Heart failure, peripheral edema, anemia, hypercholesterolemia, dose-related increase in body weight; VDSH infection, pulmonary edema, inhibit inhibit the level of liver enzymes, bone fractures. appointed at any time during the 60 minutes before morning or evening meal (or before two meals a day, among whom are 6-hour or greater period of time). Method of production of drugs: Table.
